Study Evaluates Utility of Masimo SpHb® During High-Blood-Loss Oncosurgery
In the study, Dr. Gupta and colleagues sought to evaluate the utility of
SpHb measurements on patients undergoing oncosurgery because
oncosurgeries “may be associated with large blood loss, requiring
repeated haemoglobin estimation for deciding the need for intraoperative
blood transfusion.” They enrolled 50 adult patients with anticipated
blood loss of at least 20%. During surgery, the patients’ SpHb was
continuously monitored using a Masimo Radical-7® Pulse
CO-Oximeter®. The researchers obtained venous blood samples,
which were analyzed using a
A total of 137 paired (SpHb and LabHb) data points were recorded for final analysis, including 66 at which packed red blood cell transfusions were made. The accuracy of SpHb in comparison to LabHb was assessed using Bland-Altman analysis. The level of agreement between SpHb and LabHb for the 66 transfusion data points showed a 73% correlation (p < 0.001), bias of -0.313 g/dL with standard deviation of ± 1.06 g/dL, and limits of agreement of -2.44 g/dL and 1.81 g/dL. The level of agreement between SpHb and LabHb for all 137 data points showed a 72.7% correlation (p < 0.001), bias of -0.376 g/dL with standard deviation of ± 1.27 g/dL, and limits of agreement of -2.92 g/dL and 2.16 g/dL.
The researchers concluded that, “Continuous SpHb monitoring can aid us regarding early blood transfusion decisions in oncosurgical patients along with other measures such as clinical judgement by attending consultant and haemodynamic variables. It may improve the intraoperative management of oncosurgeries by helping in real time and continuous decision-making for blood transfusion.” They also noted that SpHb “allows the physician to focus on the haemoglobin trend and detect either a slow decrease or a significant rapid drop in haemoglobin and therefore decide the appropriate time to perform an invasive measurement of haemoglobin.”
As limitations, the researchers stated that they “collected venous blood sample from central venous line rather [than] arterial blood. Haemoglobin concentration has been reported to be higher in venous blood than arterial blood though precision for haemoglobin estimation is higher for venous blood.” In addition, they suggested that further research may be needed to assess the effect of colloid administration and skin temperature at the probe site on SpHb accuracy, as well as its accuracy on patients with blood loss rates differing from the “massive but steady” rates observed in this study.
SpHb monitoring is not intended to replace laboratory blood testing. Blood samples should be analyzed by laboratory instruments prior to clinical decision making.
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Gupta N, Kulkami A, Bhargava AK, Prakash A, and Gupta N. Utility of
noninvasive haemoglobin monitoring in oncosurgery patients. Indian
July 2017; Volume 61; Issue 7; 543-548.
ORi has not received
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Masimodata on file.
This press release includes forward-looking statements as defined in
Section 27A of the Securities Act of 1933 and Section 21E of the
Securities Exchange Act of 1934, in connection with the Private
Securities Litigation Reform Act of 1995. These forward-looking
statements include, among others, statements regarding the potential
effectiveness of Masimo SpHb®. These forward-looking
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could cause our actual results to differ materially and adversely from
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risk factors, including, but not limited to: risks related to our
assumptions regarding the repeatability of clinical results; risks
related to our belief that
Evan Lamb, 949-396-3376